Research

A few years ago, some Islamic Medicine experts did a research about plaque and gingivitis caused by using ordinary toothpaste  in compare to the Siwak toothpaste. As the objects of the research they created 4 groups, which each were instructed to use different type of toothpaste:

Plaque Percentage

Siwak group showed an increased plaque percentage in the first and second week but there was a decrease in this percentage by the end of the fifth week to give a difference between that of the first week of - 3.50%.
Powdered Siwak showed a greater amount in the difference between first and fifth week scores (-11.20%) i.e. a greater ability of this substance when mechanically applied in a proper manner to rid the mouth of bacterial plaque.
Starch gave the worst scores of plaque percentage since the start of the first week. This score kept rising to give a difference in reading between first and fifth week of +14.90% i.e. a greater aggregation of plaque in the group using this material.
Commercial powder gave a low score of plaque percentage from the start and kept dropping in a similar pattern given by powdered Siwak but the values differed in both cases.

Gingivitis Percentage

Gingivitis percentage scores were recorded lowest in the powdered Siwak group from the first week of the experimental period. All scores for the different materials used kept dropping except those of starch and commercial powder group, which indicates a deterioration of the gingival condition of both groups (differences between scores of first and fifth week are 42.40% and 14.80% respectively to the worse side).

There are other side effect found in which noticeable as importance in this investigation:

It could be concluded that Siwak and powdered Siwak are excellent tools for oral cleanliness. Because of its availability in this part of the world, being inexpensive and readily adopted by Moslems as part of their religious regimen, it is highly recommended in implementing a preventive dental health program in Islamic countries.

Salvadora Persica

Salvadora Persica has been known by public in Arab, Africa and India as a "cleaner teeth tree", used as a toothbrush and twig chew. Suggested that healthy mouth and cared teeth through traditional way for African has produced huge non-cryogenic food, together with mechanism clean act that uses chewing stalk, rather than consequences from the activity of special antibacterial from that stalk it’s self.

For so long, there are big demand for Salvadora Persica Linn material from pharmacy industries in Europe. And it has been approved that toothpaste containing botanical extract mentioned previously is good for keeping the teeth,gums healthy and whitening the teeth as well.
Although fat analysis of Salvadora Persica Linn and S. Oleoides seeds has been done in detail, there is no chemical composition of their shaft,stalks, roots or leave reported in literature. Dymock, Warden, and Hooper (1889 - 1893) had given some evidence of the chemical data. According to their report the bark contains 27, 06% ashes. Moreover, still from their report, those seeds also contain a lot of chlorine and trimethylamine, chloride, a little amount of resin, beside unknown alkaloid.
Trimethylamine, as toothpaste material, is useful for removing tartar and other stain from the teeth. As desert plants, the roots and stalks contain a large number of silicon which -with mechanical movement- is useful for making the teeth sparkling.
The resin part may be useful to compose layer on the teeth enamel for protecting the teeth. Beside that, the sulfur compound, commonly known as the "mostar tree" with its smell and spicy taste, is famous as a bactericidal element.

Vitamin C:Meanwhile, the vitamin C -found in the sulfur organic compound- can help to recover gums bleeding and peels coral teeth.
The latest report by Attar showed that fibrous plant contains sodium bicarbonate, which is well known as effective toothpaste material as n action for medium germicidal. Collected pharmacology data about this plant showed antibiotic, anti-inflammatory hypoglycemic activity and anti cryogenic effect.
Salvadora Persica L uses as cleaner stalk since more than 1000 years. Extract from that plants produce sulfur as of a lot of main element. Beside that, pharmacology data is showing antibiotic, anti-inflammatory and activates hypoglycemic.
Salvadora Persica L is publicly known in Arab, Africa and India as a "cleaner teeth tree", used as a toothbrush and twig chew. Suggested that healthy mouth and cared teeth through traditional way for African has produced huge non-cryogenic food, together with mechanism clean act that uses chewing stalk, rather than consequences from the activity of special antibacterial from that stalk its self.

Fluoride

Dental caries is now thought to be due in large part to the acquisition of fluoride ions by the tooth enamel, directly or through a hydrolysis mechanism.
Since the advent of fluoride dentifrice's 30 years ago, it has been a goal of dental research efforts to identify more effective formulations.
Dentifrice's containing Sodium Fluoride (Na F) and Sodium Mono Fluorophosphate (SMFP) have been shown to be effective against caries, when used in conjunction with customary oral hygiene practices and professional care.